Synthesis of cyclic oligopeptides containing an Arg-Gly-Asp (RGD) sequence.
نویسندگان
چکیده
The synthesis of cyclic RGD peptides with 8-10 residues cyclized by an amide bond and the relationship between their structure and activity (i.e. circular dichroism spectrum and inhibition of platelet aggregation) are reported. The linear peptides were synthesized by the solution method and their cyclization was performed in high dilution using DPPA.
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عنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 47 12 شماره
صفحات -
تاریخ انتشار 1999